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How to Level Up Your Skincare Game By Layering Serums

It's officially happy hour—only instead of creating your signature drink, we're diving deep into the proper ways to mix up your skincare!

By the end of this article, you’ll feel like a proper beauty guru who’s able to confidently layer your skincare serums. In this guide, we’re celebrating our skin-loving Bye Bye Serums, which consist of four concentrated serums designed to target the appearance of skin texture, dull skin, dark spots, and fine lines.

Keep reading to learn how to properly layer skincare serums to get the most bang for your buck. We're also giving you the lowdown on which of our serums are designed for day and which are designed for use at night. Cheers!

Skincare Serum Layering Rules of Thumb

Now that you’re better versed in how to layer our skincare serums, we’ll leave you with some rules of thumb to keep in your back pocket: 

1. Do a Patch Test: When layering multiple formulas in a single regimen, we suggest “patch test” by applying product(s) together on a small area before applying to your entire face. If sensitivity such as redness, burning, or itching occurs, do not use the product or product combination.

2. Go From Thin to Thick: When layering our skincare serums on top of each other, start with the thinnest consistency and move to thickest. For example, you’d use your serums first, followed by your moisturizer since it’s thicker.

3. Don’t Mix Actives: Generally speaking, vitamin C, retinol, and glycolic acid shouldn’t meet each other in combination. Doing so might cause some skin sensitivity or irritation.

How to Layer Skincare Serums

How to get the most out of your skincare regimen is top of mind, but knowing which products to safely layer, requires a bit of education.

The concept of skincare layering is pretty simple: couple certain products together There’s definitely an art to knowing how to layer skincare ingredients and we’re using our four Bye Bye Serums to show you how it’s done. 

But first, let’s quickly introduce each of them: 

  • Bye Bye Lines : A powerful plumping and smoothing combination with hyaluronic acid, peptide, and vitamin B5 (pantothenic acid)
  • Bye Bye Dullness : A radiance-enhancing duo of vitamin C and E
  • Bye Bye Pores : A texture-refining blend of glycolic acid and hyaluronic acid
  • Bye Bye Dark Spots : A mix of niacinamide (vitamin B3) and ethyl vitamin C to visibly improve discoloration

Hyaluronic Acid

Think of hyaluronic acid as your cool, laid-back girlfriend who gets along with everyone. This ingredient is a humectant, meaning it attracts moisture to help skin look plump and hydrated, and to help smooth appearance of fine lines. It‘s one of the key ingredients in Bye Bye Lines, where it’s paired with a peptide and vitamin B5 to create a formula that helps support supple-feeling skin. 

Use IT: You can use products formulated with hyaluronic acid in your skincare application day and night to enjoy its hydrating, skin-smoothing benefits. 

Pair IT: For a super-smoothing pairing, apply two or three drops of Bye Bye Lines followed by four or five drops of Bye Bye Pores as part of your nightly regimen. For a serious radiance boosting fix, apply four or five drops of Bye Bye Dark Spots and then two or three drops of Bye Bye Lines for your morning routine. 

Vitamin C

Known as a skin-brightening powerhouse, vitamin C is an ingredient that is also a go-to for its antioxidant properties. Vitamin C is the shining star in Bye Bye Dullness, a formula that visibly boosts radiance and helps protect your skin against free radicals . In this concentrated serum formulation, vitamin C is combined with vitamin E to help keep your skin in good condition. 

Use IT: Due to its antioxidant powers, we recommend using vitamin C serums in the morning. We also recommend using it in conjunction with your favorite SPF and your CC+ Cream with SPF 50+.

Pair IT: Like OJ and champagne, vitamin C and niacinamide work brilliantly together. Apply two pumps of Bye Bye Dullness followed by four to five drops of Bye Bye Dark Spots. For a texture revitalizer, use Bye Bye Dullness as part of your morning regimen, then, before bed, use four to five drops of Bye Bye Pores. 

Glycolic Acid

A member of the alpha hydroxy acid (AHA) family, glycolic acid is prized for its skin exfoliating benefits. It gently sloughs away dead skin cells from the skin’s surface, revealing visibly refined skin texture and smaller looking pores. Glycolic Acid leads the way in Bye Bye Pores, where it’s formulated with hyaluronic acid to support a smoother, more supple feel. 

Use IT: We encourage using products formulated with glycolic acid in the evening since they can cause some photosensitivity when used during the day. 

Pair IT: Promote the look of smoother skin by layering four to five drops of Bye Bye Pores and two to three drops of Bye Bye Lines. If you want to double down, we recommend using your Bye Bye Pores in the evening and then your favorite vitamin C serum—like Bye Bye Dullness—in the morning. If you also like to use a retinoid, such as Hello Results Wrinkle-Reducing Daily Retinol Serum-in-Cream, these should be alternated on different nights instead of being used in the same evening. 


Niacinamide is part of the vitamin B family (of which there are 12 members), and is arguably one of the more widely used forms of the vitamin. It’s noted for its impressive ability to help even out the look of discoloration. It’s a key ingredient in Bye Bye Dark Spots, which is designed to help visibly improve dark spots and discoloration. This Concentrated Derm Serum is formulated with ethyl vitamin C, to help visibly improve overall skin clarity. 

Use IT: You can use niacinamide serums in the morning or evening. 

Pair IT: For a skin-plumping dynamic duo, layer four to five drops of Bye Bye Dark Spots with two to three drops of Bye Bye Lines. For an anti-aging option that helps refresh your complexion, apply four or five drops of Bye Bye Dark Spots followed with four or five drops of Bye Bye Pores and use at night.

It Cosmetics Bye Bye Serums

And remember, like bottomless mimosas at brunch, pairing your serums is optional. As always, rocking our Bye Bye Serums solo will also deliver the look of beautiful skin! 

Learn more about each of our Concentrated Derm Serums.

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